On the other hand, the fact that psychostimulants act on numerous pathways hampers the investigation of the neurobiology underlying the observed behavioral changes.
SFK signaling networks, in particular Lyn, appeared to be central to the basal cell phenotype, intersecting numerous pathways involving the other activated tyrosine kinases in these cells [ 41].
Of course, EGFR transduces signals through numerous pathways, and the integrated effects ultimately determine phenotypic outcomes.
This was expected since metabolites such as salicylic acid, benzoic acid, and jasmonic acid play crucial roles in numerous pathways, controlling the way in which plants grow and develop [ 74].
The molecular mechanisms of HDL/SR-BI induced signaling revealed the involvement of numerous pathways that mediate the atheroprotective actions of HDL in cells relevant to atherogenesis such as macrophages, endothelial cells, and vascular smooth muscle cells.
Besides, a great number of nanotapers can act as numerous pathways to facilitate the charge transfer, leading to the enhanced PEC efficiency.
Although WNTs were originally classified as signaling through canonical (via β-catenin) or non-canonical pathways, recent studies indicate that many WNTs activate numerous pathways, depending on the expression profile of WNT receptors (including Frizzled family members), LRP5, LRP6, ROR1, ROR2 and RYK10,11,12.
Therefore, the increased level of hnRNP K in the NM could be the critical step towards the activation of the numerous pathways involved in carcinogenesis, which are potentially regulated by hnRNP K. HnRNP K could directly or indirectly, through modifications of protein/protein or RNA complexes, modulate the transition from an open to a condensed chromatin state.
Transcription dependent upon β-catenin is increasingly being seen as the output of numerous pathways acting in synergy with the "canonical" wnt-Fz/LRP-dvl pathway.
