Sentence examples for numerous pathways including from inspiring English sources

Prosurvival signals are transmitted via numerous pathways including AKT, which plays key roles in apoptosis, tumor growth, therapy resistance of tumor cells and radiation responsiveness [25], [26], [27], [28], [29].

Early IVD degeneration involved significant changes in numerous pathways, including Wnt/β-catenin signaling.

Actually, it has been acknowledged that poverty undermines maternal, newborn and child health through numerous pathways, including reduced care-seeking and access to health care services [ 40, 41].

However, metagenomic mapping of gut bacteria indicates a highly enriched and functionally diverse genome related to numerous pathways including metabolism of carbohydrates, energy, amino acids, and vitamins [ 21].

Physical activity (PA) promotes IS through numerous pathways, including increased numbers of GLUT4 transporter proteins (which are responsible for intracellular transport of glucose) and their redistribution, an increase in muscle mass (and specifically an increase in insulin-sensitive muscle fibers), as well as capillary recruitment and proliferation and enhanced cellular insulin signaling (3, 4).

We found that these phenotypes could be rescued by intervening in numerous biological pathways, including IGF-1/insulin signaling, mitophagy, and the mitochondrial unfolded protein response, suggesting that it may be possible to ameliorate mtDNA disease through multiple molecular mechanisms.

Central nervous system (CNS) development is orchestrated by numerous signaling pathways, including the Shh signaling pathway, which in mammals is mediated by the transcription factors Gli 1, 2, and 3 (reviewed in [1] [3]).

The Cyp2 family of cytochrome p450 epoxygenases generate biologically active eicosanoids that act as second messengers in numerous signalling pathways, including those mediated by PKB/Akt, to regulate various processes including apoptosis [73].

The effect of antiestrogens in S-phase is most likely indirect by affecting numerous signalling pathways, including the AKT phosphorylation activity which activates Chk1 and other factors necessary for replication origin firing.

Numerous signaling pathways, including Wnt, BMP, and Notch signaling pathways, regulate cell fate decisions during MSC differentiation and can be utilized to influence lineage choices in vitro [ 3– 5].

Cancer metastasis is a multi-faceted process requiring the disregulation of numerous signaling pathways, including those associated with cell adhesion and motility.