PrPC function in protein S-nitrosylation may also guide the study of the numerous cellular pathways in which PrPC is involved.
There are numerous pathways, in addition to the canonical Wnt pathway, which regulate β-catenin.
The biochemical pathways in which EPHX1 participates involve numerous enzymes.
Prosurvival signals are transmitted via numerous pathways including AKT, which plays key roles in apoptosis, tumor growth, therapy resistance of tumor cells and radiation responsiveness [25], [26], [27], [28], [29].
We focused on the two well-described, convergent pathways in which mTOR acts as key regulator: the PI3K-AKT-mTOR pathway and the RAS-MAPK-mTOR pathway.
Therefore, the increased level of hnRNP K in the NM could be the critical step towards the activation of the numerous pathways involved in carcinogenesis, which are potentially regulated by hnRNP K. HnRNP K could directly or indirectly, through modifications of protein/protein or RNA complexes, modulate the transition from an open to a condensed chromatin state.
This was expected since metabolites such as salicylic acid, benzoic acid, and jasmonic acid play crucial roles in numerous pathways, controlling the way in which plants grow and develop [ 74].
There are numerous suspected pathways through which living in a poor neighborhood could lead to higher risks of heat-related deaths.
SHB is a multifunctional adaptor protein potentially affecting numerous signaling pathways which were investigated in postnatal ovaries to obtain a mechanistic explanation for the alterations in follicle and oocyte development observed.
There are numerous other pathways which are perturbed in prostate cancer by the treatments used here, as well as epigenetic and genetic variability which likely account for the remaining unexplained variance in cell survival, however a majority of cell survival can be explained by these 8 phosphoproteins' activation level at three time points.
