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Growing evidence suggests that EVs in the systemic circulation are involved in numerous pathophysiological processes including cardiovascular disease and cancer, but their role in kidney stone pathophysiology, either in the blood or urine, is not established.
Numerous pathophysiological processes are known to be associated with the development of IR.
Estrogens regulate numerous pathophysiological processes, mainly by binding to and activating estrogen receptor (ER)α and ERβ.
Lipid peroxidation leads to an elevated oxidative stress in cells and induces numerous pathophysiological processes for disease development.
Estrogens are a group of steroid compounds involved in numerous pathophysiological processes, including in the development of hormone-sensitive tumors (Ascenzi et al., 2006; Yager and Davidson, 2006).
In general, PCSKs are ubiquitously expressed and mediate numerous pathophysiological processes [ 129, 130], such as the conversion of inactive precursor proteins into biologically active products that are vital for several biological functions.
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Hydrogen sulfide (H2S) is a critical biological messenger in numerous physiological and pathophysiological processes.
Oxidants play a role in numerous physiological and pathophysiological processes, many of which rely on transport in and out of the nucleus.
Genetic evidence has revealed the role of NRs in numerous physiological and pathophysiological processes, and biochemical evidence has revealed that they are highly amenable to pharmacological manipulation.
The oxidative status of a biosystem represents a relative level of oxidation in living organisms and is crucial for understanding numerous human physiological and pathophysiological processes [ 1].
Reflective of its diverse roles in normal biological and pathophysiological processes, numerous serine kinases signal through STAT3 via Ser727 phosphorylation, including mTOR (39), PKC (40), RIPK-1(28), and the 3 major MAPK pathways: ERK, p38, and JNK (41, 42).
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