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Immunological tolerance is a fundamental process, the lack of which would result in numerous pathologies including autoimmune illnesses.
Disruption of gastrointestinal homeostasis, as a result of impaired barrier function, is associated with numerous pathologies including inflammatory bowel disease and colorectal cancer.
The pool sizes and ratios of the pyridine nucleotides NAD(P)+ and NAD(P H play a fundamental role in cellular metabolism and have emerged as key factors in numerous pathologies, including mitochondrial disorders, neurodegenerative diseases, cancer and aging.
Patients with UPD14 have numerous pathologies including cardiomyopathy, dwarfism, short limbs, mental retardation, scoliosis, musculoskeletal abnormalities, and intrauterine growth defects [70], [71], [72].
Dysregulation of the haematopoietic differentiation programme is at the origin of numerous pathologies, including leukaemias.
Inhalation of silica is associated with numerous pathologies including tuberculosis, lung cancer, chronic obstructive pulmonary disease, and silicosis [ 246].
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STAT1 and STAT3, members of the cytoplasmic family of signal transducers and activators of transcription factors (STAT), have been associated with numerous inflammatory pathologies, including inflammatory bowel disease, hepatitis, and acute lung injury.
Numerous clinical pathologies including metastasis, an invasive form of cell migration, have been linked to abnormal GPCR signaling.
CX3CL1 is involved in the development of numerous inflammatory pathologies including rheumatoid arthritis and graft rejection.
Osteogenic media was used throughout the in vitro experiments because the addition of exogenous phosphate to investigate mineralisation potential is routine in mineralisation studies of numerous other pathologies, including osteoblasts and vascular smooth muscle cells in vitro (Shioi et al, 1995; Coelho and Fernandes, 2000).
The pluripotent ES cells will be a valuable source in the treatment of numerous functional degenerative pathologies including Parkinson's disease (PD), which is characterized by progressive and selective loss of dopaminergic neurons in the midbrain substantia nigra.
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