In case of deregulation, TNF is implicated in numerous pathologies.
Improving lower-limb flexion/extension angles during walking is important for the treatment of numerous pathologies.
Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc is implicated in numerous pathologies.
Disruption of gastrointestinal homeostasis, as a result of impaired barrier function, is associated with numerous pathologies including inflammatory bowel disease and colorectal cancer.
In the overlap of biochemical processes which have been identified in AD and VaD, oxidative stress is believed to contribute to the numerous pathologies of both dementias.
In particular, reproducing the Golgi glycosylation system in vitro would allow the synthesis of bioactive glycan polymers and glycoconjugates for many future applications including treatments of numerous pathologies.
In the heart, numerous examples of contractile protein changes correlate with functional alterations, both during normal development and during the development of numerous pathologies.
Membrane proteins play a key role in numerous pathologies such as cancer, cystic fibrosis, epilepsy, hyperinsulinism, and Alzheimer's disease, yet studies on these and other disorders are hampered by a lack of information about the proteins involved.
Due to the prominent roles of membranes in the cells' physiology and the paucity of therapeutic approaches based on the regulation of the lipids they contain, it is expected that membrane lipid therapy will provide new treatments for numerous pathologies.
Hydrogen sulfide (H2S) is a biologically generated, gaseous signaling molecule that mediates a wide range of physiological functions and is misregulated in numerous pathologies ranging from neurodegenerative disease to hypertension to diabetes.
The pool sizes and ratios of the pyridine nucleotides NAD(P)+ and NAD(P H play a fundamental role in cellular metabolism and have emerged as key factors in numerous pathologies, including mitochondrial disorders, neurodegenerative diseases, cancer and aging.
