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Numerous new agents are specifically addressing resistance mechanisms; mature data are related to the T790M mutation and MET pathway activation.
Despite the development of numerous new agents over the past two decades and the rare durable remission, MBC remains an incurable disease.
He outlined some of the current challenges that we face in assay development for any new target, and how molecular pathology needs to be integrated into early-phase trial design in order to maximise the potential of the numerous new agents that are now available for clinical investigation.
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Thus, for many years, numerous attempts have been made to develop new agents capable of preventing and/or treating periodontitis (Park et al. 2005).
Numerous preclinical studies have reported neuroprotective effects of new agents in animal studies.
There are numerous new therapeutic approaches that are under development, including anti-inflammatory agents, secretory stimulants, and tear film stabilizers; as a result, as improved endpoints are incorporated into clinical trials, it is likely that multiple therapeutic agents will emerge in the foreseeable future [4].
There are numerous new F.B.I. e-mail messages and memorandums that fill in the details of agents' suspicions and why they were not heeded.
However, since the publication of Trinh meta-analysis, numerous new trials have been published that investigated further the role of ChEIs as a psychotherapeutic agent in AD.
Numerous clinical trials are currently underway in cohorts of patients with breast and prostate carcinoma to investigate new agents capable of blocking multiple family members such as lapatinib (Bublil and Yarden, 2007).
As a result, numerous new companies emerged.
Numerous new ventures emerged during this period of growth.
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