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Indeed, numerous mutations within the viral glycoproteins have been shown to reduce the dependence of HCV to utilize SR-B1 as an entry receptor, thereby making them more resistant to anti-SR-B1 therapy in cell culture.
Although here we show correction of a single-point mutation that causes CGD, there are numerous mutations within the CYBB gene, as well as within the CYBA, NCF1, NCF2 and NCF4 genes, that are also responsible for CGD in different patients.
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The Cancer Genome Atlas project (TCGA) revealed adult HGA to be highly heterogeneous with numerous mutations and copy number changes within tumors and across tumors sharing similar gene expression profiles [ 8, 12, 52, 72].
One is to create numerous mutations in a single gene.
Directed evolution works by making numerous mutations in a gene that produces a particular protein.
Numerous mutations in crystallins have been identified to cause autosomal dominant congenital cataracts (ADCCs) and the list of mutations is increasingly risen every year (Shiels and Hejtmancik, 2015).
Subsequently numerous mutations in the protein were directly identified by sequencing.
However, most ERVs are inactivated by numerous mutations.
Moreover, numerous mutations have been found in the LIPH gene.
Numerous mutations were observed.
Numerous mutations have accumulated in the sequence, but several exons (2a, 2b, 4, 5, 6, and 7) were identified using UniDPlot within the 10 kb upstream φ AMBN.
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