Exact(3)
Numerous mutations were observed.
Numerous mutations were accumulated (substitutions and indels), producing a φ AMTN sequence that is now hardly recognizable from the non-coding gDNA.
After the identification of the Aβ peptide, initially in vessels of trisomy 21 patients and then in senile plaques of AD cases [ 105, 208, 341], several teams looked for "the" mutation responsible for the rare cases of familial Alzheimer disease (FAD only to realize that not one but numerous mutations were actually able to cause the disease.
Similar(57)
7 Protection of cells against accumulation of numerous mutations is carried out by DNA repair enzymes.
In both phylogenies numerous mutations are located at tips of the network, and are derived from ancestral haplotypes at the interior nodes in the network.
Finally, as numerous mutations are causally linked with different forms of inherited neuropathies, our findings suggest a need for detailed investigations into associations of potential JAM-C mutations with neural disease.
Numerous novel mutations were unraveled including a second prevalent mutation, Y42H (c.189T>C) (3, 18– 20).
Numerous synonymous mutations were identified as well, but no frameshift, nonsense or splice site mutations were found, suggesting that severe loss of function mutations in RNF213 may not be tolerated.
The finding that numerous lobe mutations were identified in our study as well as in termination screens of bacterial RNAP and yeast Pol III (Landick et al. 1990, Shaaban et al. 1995) was initially somewhat surprising.
26 Interestingly, when many of the other DRV-RAMs were included in a wild-type genetic background by site-directed mutagenesis, they did not cause decreased susceptibility to DRV, suggesting numerous additional PI mutations were required for resistance.
This fateful mutation, when coupled with numerous other mutations, was responsible for the origins of eyes and vision in animals.
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