Nonetheless, the greater challenge will be decoding the extraordinary breadth of the sequence data in the quest to determine which of the numerous mutations in the genome are causative and which are simply passenger events (Stratton, 2011).
While the crossreactive antibody CK138 predominantly gathered mutations within the CDRs, CK157 collected numerous mutations within the framework regions (FWRs) (Fig. 3b, c and Supplementary Fig. 6).
Although here we show correction of a single-point mutation that causes CGD, there are numerous mutations within the CYBB gene, as well as within the CYBA, NCF1, NCF2 and NCF4 genes, that are also responsible for CGD in different patients.
Indeed, numerous mutations within the viral glycoproteins have been shown to reduce the dependence of HCV to utilize SR-B1 as an entry receptor, thereby making them more resistant to anti-SR-B1 therapy in cell culture.
Numerous mutations in the X-linked EDA gene have been identified as the cause of disease in human [ 6- 8] and mouse [ 3, 9].
[1] Although numerous mutations in the CF gene have been described, there is little correlation between the specific mutation in the CF gene and severity of pulmonary disease.
Overall, mutations in MYH7 are predominantly missense mutations located in the globular myosin head, potentially affecting the binding sites for actin or nucleotides but there are also numerous mutations in the rod region.
Subsequently numerous mutations in the protein were directly identified by sequencing.
Almost all elements analyzed carried numerous mutations suggesting the presence of a RIP-like mechanism in M. graminicola.
Two of these VDPV2s carried numerous mutations in the VP1 region (903 bp): isolates MAD-2593 11 MAD-2593 11tiont) and mutations11 (33 nt mutandons).
