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In both phylogenies numerous mutations are located at tips of the network, and are derived from ancestral haplotypes at the interior nodes in the network.
Finally, as numerous mutations are causally linked with different forms of inherited neuropathies, our findings suggest a need for detailed investigations into associations of potential JAM-C mutations with neural disease.
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Numerous mutations were observed.
7 Protection of cells against accumulation of numerous mutations is carried out by DNA repair enzymes.
Numerous mutations were accumulated (substitutions and indels), producing a φ AMTN sequence that is now hardly recognizable from the non-coding gDNA.
After the identification of the Aβ peptide, initially in vessels of trisomy 21 patients and then in senile plaques of AD cases [ 105, 208, 341], several teams looked for "the" mutation responsible for the rare cases of familial Alzheimer disease (FAD only to realize that not one but numerous mutations were actually able to cause the disease.
This is in the core 507 533 region, in which numerous mutations have been observed to cause resistance to RIF, although mutations at other sites in this region are more frequent (mutations specifically at Asp 435 constitute only 9% of all RIF-R cases).
Numerous mutations have been reported in DDR1, but whether it may represent an attractive anticancer target is currently unclear.
Numerous mutations have been described in the RB1 gene but several other genes have also been implicated to play a role in retinoblastoma.
Moreover, numerous mutations have been found in the LIPH gene.
Numerous mutations have been found in the protein-binding domain of IRF6 in VWS patients.
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