One is to create numerous mutations in a single gene.
Directed evolution works by making numerous mutations in a gene that produces a particular protein.
Nine separate neighbourhoods are called La Palma, four are called Las Palmas, and there are numerous mutations: La Palmita, Las Palmitas, Palmas Inn, La Palma Condominio, Palmas Axotitla, La Palma 1 and Palma I-II Unidad Habitacional.
Moreover, a full fetal genome sequence would turn up numerous mutations for which information is lacking as to whether they cause disease, posing a dilemma for expectant parents and their doctors.
Evolutionary approaches are often undirected and mutagen-based yielding numerous mutations, which need elaborate screenings to identify relevant targets.
In contrast, pseudogene 2, containing numerous mutations in all parts of the retrotransposon, was not expressed in any tissue.
Direct molecular diagnosis remains the most decisive tool but is often hindered by demanding techniques and numerous mutations.
Numerous mutations have been described in the RB1 gene but several other genes have also been implicated to play a role in retinoblastoma.
Numerous mutations in crystallins have been identified to cause autosomal dominant congenital cataracts (ADCCs) and the list of mutations is increasingly risen every year (Shiels and Hejtmancik, 2015).
The results from each of these different technologies have yielded numerous mutations that modify Fc-FcγR interactions and the resultant effector functions (Table 1).
This may be ensured by the generation of large mutations (particularly deletions), numerous mutations with epistatic interactions, or chimeric viruses in which the structural proteins of a well-attenuated virus are replaced with those of the virus targeted for immunization.
