Sentence examples for numerous mutation events from inspiring English sources

Most human tumors harbor numerous mutation events leading to activation of multiple signaling pathways.

Although numerous single mutational events occur in parC, the focus of this investigation was on amino acid substitutions for Ser-79 or Asp-83, because previous studies have consistently demonstrated that mutations at either of these positions are associated with decreased susceptibility (9, 14 ).

Bars indicate mutation events.

Two key features of this model are the dependence of mutation rates on microsatellite length and a mutation process that includes both strand slippage and point mutation events.

Nonetheless, the greater challenge will be decoding the extraordinary breadth of the sequence data in the quest to determine which of the numerous mutations in the genome are causative and which are simply passenger events (Stratton, 2011).

There are other examples of possible complete gene conversion events occurring between species-specific Alu elements, where pairs of elements share numerous mutations.

Yet, as repair of DSBs often is accomplished by mechanisms that cause mutations at the breakage site, providing the cell with a means to detect frequent genotoxic events would ultimately benefit the organism by inactivating cells that otherwise would have accumulated numerous mutations.

One is to create numerous mutations in a single gene.

Directed evolution works by making numerous mutations in a gene that produces a particular protein.

But as scientists began discovering a much broader array of genetic mutations linked to cancer, oncologists needed a way to screen individual patients for numerous mutations.

While the crossreactive antibody CK138 predominantly gathered mutations within the CDRs, CK157 collected numerous mutations within the framework regions (FWRs) (Fig. 3b, c and Supplementary Fig. 6).