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Its central folded domain binds DNA, while the disordered N- and C-termini act as regulatory elements that interact with different effector proteins and harbor numerous modification sites (see section 3.6).
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Based on the comprehensive analysis of these datasets by a wide array of modern bioinformatics tools it was concluded that disordered regions of PCD-related proteins are involved in a multitude of biological functions and interactions with various partners, possess numerous posttranslational modification sites, and have specific evolutionary patterns (Peng et al. 2013).
Enzyme-mediated modification sites on numerous substrates could be revealed by large-scale proteomic analysis of enriched peptides.
Linear motifs can be broadly divided into two major families: those that act as modification sites and those that act as ligands, with each having numerous subgroups.
This method can be used to map RNA protein binding sites or RNA modification sites on a genome-wide scale.
Fig. 1 Modification sites based on compound 1.
Site annotations list any structurally/functionally important sites (molecule processing sites, binding sites, modification sites, etc).
Because of the problems of chirality, the synthetic issues, and the limited impact on the absorbance, considerably less work was devoted on substitution at the benzylic site than the very numerous modifications on the aromatic ring.
Nordic skiing underwent numerous modifications at Calgary.
For Liberty Weekend, however, the software required numerous modifications.
(c) One peptide spectral example showing the modification site.
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