Sentence examples for numerous mediators including from inspiring English sources

The PGs located in mast cell granules are mainly of the serglycin type, and these exert a key role in promoting the storage of numerous mediators, including histamine, serotonin and several mast cell proteases [11] [16].

Numerous mediators, including cytokines, kinins, complement, coagulation factors, and eicosanoids, are activated or systematically released, resulting in profound disturbances of cardiovascular and organ system function.

The activated STAT1 pathway can modulate the expression of numerous inflammatory mediators, including chemokines [ 14].

In addition to inflammatory cells, there is evidence that numerous other mediators including substance P, MMPs, VEGF and COX which play a role in chronic tendon pathology.

The formation of GRE involves numerous molecular mediators, including VEGF, aquaporins (AQP), Cox-2, inflammatory mediators, nitric oxide (NO), and the tight junction relative protein between capillary endothelial cells.

PLA2 hydrolyzes membrane phospholipids to produce fatty acids, including arachidonic acid and lyso-phospholipids, and thus it initiates the production of numerous inflammatory mediators including arachidonic acid derived eicosanoids (prostaglandins, thromboxane and leukotrienes), platelet-activating factor and the various lyso-phospholipids themselves.

Additionally, numerous soluble mediators, including TNF-α [ 18], TGF-α [ 19], TGF-β [ 20], IL-1β [ 21], IL-1α [ 22], IL-6 [ 23, 24], IL-8 [ 25], VEGF [ 26], and others have been implicated in PC carcinogenesis, tumor progression, and treatment resistance.

Numerous cytokines and inflammatory mediators, including IL-1, IL-6, IL-12 and TNF-α, are documented to be released in the early phase of sepsis, while HMGB1 is released at the late phase [ 7]. High serum concentrations of TNF-α are correlated with sepsis-induced mortality [ 31].

Mast cells are well-known for their leading role in allergic reactions, during which they are stimulated by IgE binding to high-affinity receptors (FcϵRI), aggregation of which leads to degranulation and secretion of numerous pre-stored and newly-synthesized mediators, including IL-6 and TNF [ 192- 197].

Activated platelets release several vasoactive mediators including serotonin.

Inflammatory mediators, including cytokines and chemokines, can facilitate tumor dissemination.