Sentence examples for numerous malignancies including from inspiring English sources

Jumping translocations (JT) have been identified in numerous malignancies, including leukemia, but infrequently in patients with myelodysplastic syndromes (MDS).

Natural killer (NK) cell-mediated cytotoxicity contributes to the innate immune response against numerous malignancies, including leukemias.

PDT has been successfully applied to the therapy of numerous malignancies, including head and neck cancer11, lung cancer12, mesothelioma13, and is FDA-approved for the clinical treatment of esophageal cancer14.

HLA-G is highly expressed in numerous malignancies, including melanoma, glioma, and colorectal, hepatocellular, breast, lung, and ovarian cancers82,83,84,85,86; expression of HLA-G is associated with poor patient survival and has been confirmed as independent prognostic factor82,83,84,85.

Peutz-jeghers syndrome (PJS) is a rare autosomal dominant disease due to mutations in the tumour-suppressor gene STK11 [62], which predisposes not only to hamartomatous gastrointestinal polyps and mucocutaneous pigmentation, but also to numerous malignancies, including gynaecologic ones, the latter having a reported relative risk of 27.7 % in comparison to the general population [63].

Inflammation has been associated with the development of numerous malignancies including colorectal cancer [ 1].

Mutations in PTEN have been identified in numerous human malignancies, including cancers of the brain, endometrium, ovary, and prostate.

PTEN mutations have been identified in numerous human malignancies, including brain, ovary and prostate cancers, but they are rarely seen in carcinomas arising from the head and neck region (including esophagus) [ 26- 28].

Survivin is expressed at high levels in numerous adult malignancies including lymphomas, breast, lung, and colon carcinoma, as well as in paediatric cancers including neuroblastoma, Wilm's tumour, choroid plexus tumours, and ependymomas (Altieri, 2003b; Altura et al, 2003).

MiRNA expression patterns have been shown to be dysregulated in numerous human malignancies, including breast cancer, suggesting their probable involvement as novel classes of oncogenes or tumour suppressor genes.

The prognostic potential of apoptosis-signaling proteins such as BCL2-family members has been well documented so far in numerous human malignancies, including leukemias and lymphomas, hormone-dependent tumors, colorectal cancer, and head and neck cancer [ 11, 48].