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While radiation-based therapies are effective for treating numerous malignancies, such treatments can also induce osteoporosis.
Jumping translocations (JT) have been identified in numerous malignancies, including leukemia, but infrequently in patients with myelodysplastic syndromes (MDS).
For numerous malignancies a relationship between the intensity of antineoplastic chemotherapy and tumor response has been demonstrated.
Natural killer (NK) cell-mediated cytotoxicity contributes to the innate immune response against numerous malignancies, including leukemias.
Imatinib mesylate, a tyrosine kinase inhibitor currently used in the clinical setting for treatment of numerous malignancies, decreased the viability of CAFs in vitro by inhibiting expression of alpha-SMA [127].
Peutz-jeghers syndrome (PJS) is a rare autosomal dominant disease due to mutations in the tumour-suppressor gene STK11 [62], which predisposes not only to hamartomatous gastrointestinal polyps and mucocutaneous pigmentation, but also to numerous malignancies, including gynaecologic ones, the latter having a reported relative risk of 27.7 % in comparison to the general population [63].
Similar(24)
Activated by EGFR or other RTKs, STAT3 proteins cooperate with other transcription factors to regulate expression of numerous malignancy related genes, including bcl-2, bcl-xL, mcl-1, p21WAF1/CIP1, MMP-9, and Cyclin D1.
Ovarian carcinoma is the most common prototype malignancy to produce omental cakes; however, numerous other malignancies may have a similar or forme fruste appearance.
It has been found to be amplified, overexpressed, or constitutively activated in numerous human malignancies with oncogenesis derived from the simultaneous promotion of cell survival and suppression of apoptosis.
TICs have now been identified and characterized in numerous human malignancies.
High expression levels of the human DEK gene have been correlated with numerous human malignancies.
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