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Retrotransposon-based markers reveal numerous loci at a time but are dominant.
Recently, several genome-wide association studies (GWAS) have independently found numerous loci at which common single-nucleotide polymorphisms (SNPs) modestly influence the risk of developing colorectal cancer.
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We found associations between methylation at numerous loci and genotype at the functional Val 158 Met SNP (rs4680), and most of the correlations between methylation and demographic and alcohol use factors were Val 158 Met allele-specific.
Human disease models developed in non-inbred but genetically defined animals are better able to reflect the complexities of those human diseases with familial patterns of inheritance due to variants of genes at numerous loci with potential to contribute to the disease phenotype.
This admixture results in significant heterozygote deficiencies at numerous loci.
As expected, we found CTCF at numerous loci across the regions included on the array.
Genome-wide association studies have accelerated the discovery of single-nucleotide polymorphisms (SNPs) at numerous loci.
This admixture results in significant heterozygote deficiencies at numerous loci due to Wahlund effects.
Validation of genome-wide DNA methylation results is crucial, considering that the average beta values between smokers and non-smokers at numerous loci differed merely by about 0.1.
Populations previously described in the literature [ 7, 40], as phenotypically mixed, O8 and N3, presented significant deviations from HWE at numerous loci: 13 and 16 out of 25 loci scored, respectively (Additional File 3).
Two studies of ZFNs that used unbiased methods to identify off-target genomic sites for several ZFN pairs documented infrequent off-target effects at numerous loci in a cultured human tumor cell line (Gabriel et al., 2011; Pattanayak et al., 2011).
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