Kir channels are expressed in a wide variety of cells including skeletal, cardiac, and vascular myocytes, neurons, and pancreatic β-cells and play numerous key physiological roles including stabilizing the resting membrane potential, regulating K+ ion flux across cellular membranes, and regulation of cellular excitability [18].
In ALS, in the brainstem and spinal cord of both patient and animal models, increasingly large numbers of activated microglia and astrocytes, IgG, and T lymphocytes [13], [34] [36] may be capable of secreting the numerous cytokines playing key roles in the inflammatory reaction.
Analyses of mouse models with female fertility defects have revealed numerous gene products with key roles at various stages of ovarian folliculogenesis [2].
Enzymes serve key roles in numerous biotechnological processes and products that are commonly encountered in the forms of food and beverages, cleaning supplies, clothing, paper products, transportation fuels, pharmaceuticals, and monitoring devices.
Networks of protein-protein interactions play key roles in numerous important biological processes in living subjects.
These neurotransmitters play key roles in numerous physiological activities of various species (Rock 1968; Fagg and Foster 1983; Wroblewski and Danysz 1989; Advokat and Pellegrin 1992; Navarro et al. 1998; Burton and Kazemi 2000).
This protein complex, which is located primarily in the nucleus (Bertinato et al, 2001; Koike et al, 2001), has key roles in numerous cellular processes, including DNA repair, chromosome maintenance and regulation of transcription (Ramsden and Gellert, 1998).
Enzymes play key roles in numerous biotechnology products and processes that are commonly encountered in the production of food and beverages, cleaning supplies, clothing, paper products, transportation fuels, pharmaceuticals, and monitoring devices.
Prosurvival signals are transmitted via numerous pathways including AKT, which plays key roles in apoptosis, tumor growth, therapy resistance of tumor cells and radiation responsiveness [25], [26], [27], [28], [29].
Numerous researches observed that UCP2 plays key roles in regulation of ATP production and maintaining cellular energy balance.
