Sentence examples for numerous inflammatory and from inspiring English sources

Mast cells contain vesicles comprising numerous inflammatory and vasodilatory substances (Fig. 5) and undergo degranulation upon activation by exogenous allergens or endogenous stimuli [60].

The complement activation has been demonstrated in numerous inflammatory and degenerative, acute and chronic, diseases of the brain [ 3].

IL-1 has been implicated as a pathogenic mediator in numerous inflammatory and degenerative conditions, including rheumatoid arthritis (RA) and osteoarthritis (OA) [ 1].

Although under normal circumstances C5a-mediated C5aR activation is highly favorable, excessive levels of C5a can be deleterious to the host and have been related to numerous inflammatory and autoimmune diseases (e.g. rheumatoid arthritis, inflammatory bowel disease and reperfusion injury).

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine, released by a variety of cell types and is involved in numerous inflammatory and autoimmune diseases (Calandra and Roger, 2003).

As shown here, as well as by others, IL-1 abruptly shifts the metabolism of the chondrocyte stimulating the expression of numerous genes, such that the cells responsible for maintenance of the articular cartilage matrix are converted into effector cells that degrade the matrix and produce numerous inflammatory and chemoattractant molecules.

Macrophages, one of the phagocytic cell lineages presented in most tissues, contribute to the innate immunity and are responsible for numerous inflammatory, immunological, and metabolic processes [ 5].

Steroid hormones, acting through their cognate receptors, are critical regulators of gene expression during development, differentiation, homeostasis, and endocrine therapies for numerous inflammatory diseases and lung development in premature infants.

By using multidisciplinary analysis of corpora amylacea inclusions in prostate glands of patients diagnosed with prostate cancer we have revealed that their major components are the amyloid forms of S100A8 and S100A9 proteins associated with numerous inflammatory conditions and types of cancer.

These two cytokines, produced at high levels by macrophages localized in the lining layer and at the pannus lesion, induce the synthesis of numerous inflammatory mediators and matrix-degrading enzymes via the activation of the transcription factor NF-κB and the mitogen-activated protein kinase (MAPK) cascade [ 15, 16].

Vulnerable plaques are generally characterized by a lipid and vascular rich plaque with an overlying thin fibrous cap, containing numerous inflammatory macrophages and VSMCs.