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Numerous histone modifications include (not exclusively) acetylation, methylation, and phosphorylation.
Among numerous histone modifications, trimethylation of histone H3 lysine 9 (H3K9) is associated with chromatin compaction and decreased expression [ 31].
Numerous histone modifications are associated with different levels of gene expression, most prominently H3K4 trimethylation as an indicator of active transcription, and H3K27 trimethylation as an indicator of inactive genes.
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Among numerous histone modification enzymes studied a recurrent theme is that the enzymes or their associated protein complexes are capable of interacting with histones [ 37, 38].
The 'regulatory features' track in the 'region in detail' view reveal DNase I hypersensitive sites and numerous histone modification and methylation sites aligning to the 5'UTR and upstream region of MYO6 transcripts.
Observing numerous genes where histone modifications and transcripts co-vary was expected.
Much of this complexity results from the presence of numerous histone post-translational modifications and histone variants.
The analysis of cancer cells epigenomes also revealed numerous aberrations in histone modifications including histone acetylation and methylation.
In this context, numerous histone post-translational modifications (PTMs) have been described that include acetylation, phosphorylation, methylation, ubiquitylation and SUMOylation [ 1].
Histone modifications occur in a dynamic fashion and numerous enzymes that introduce histone modifications have been identified, as well as various enzymes that specifically remove these modifications.
How does this translation reflect the numerous different types of histone modifications, as well as RNA inference, which are mostly "deep inside" epigenetic features?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com