Sentence examples for numerous genetic mutations from inspiring English sources

Because the progression of a normal cell to a cancer cell involves numerous genetic mutations, targeting one or even several gene products may be ineffective.

During this process numerous genetic mutations are lost from the population while mutations which occur concurrently with drug resistance causing mutations (or 'hitchhiking SNPs') remain [ 14].

We hypothesise that during the course of infection numerous genetic mutations arise within a mycobacterial population and in response to a selective pressure such as antibiotic exposure, clones with pre-existing drug resistant mutations are selected.

The inner ear is highly sensitive to damage, and numerous genetic mutations and environmental insults lead to hearing loss (Dror and Avraham, 2009; Rybak and Ramkumar, 2007; Sliwinska-Kowalska and Davis, 2012).

The inner ear hair cells, which detect sound and transmit it to the brain, are highly sensitive to damage, and numerous genetic mutations and environmental insults, particularly exposure to ototoxic drugs such as aminoglycoside antibiotics and chemotherapeutics, can lead to hearing loss.

The expression of E-cadherin is regulated by numerous factors including genetic mutations, DNA methylation, and H. pylori infection.

Similarly, numerous genetic diseases harbouring mutations in distinct components involved in ribosome biogenesis, collectively referred as "ribosomopathies", are prone to developing cancer [ 9].

Head and neck squamous cell carcinoma frequently carries numerous genetic alterations, such as mutations, chromosomal losses, gains and amplifications (amp) (Gollin, 2001).

CI: confidence interval; HR: hazard ratio; n: number of samples The phenotypic heterogeneity of cancer arises as a consequence of numerous genetic abnormalities (such as somatic mutations and chromosomal aberrations) acquired during tumor development and results in the formation of a disease that is enormously complex and highly variable between patients.

Scientists have turned a natural bacterial defense system into a laboratory tool for cutting or reordering genes in a cell — an innovation that could be used to target genetic mutations linked to numerous diseases.

In addition numerous studies have shown that complete inhibition of CD18, or genetic mutations in CD18 profoundly reduce leukocyte transmigration at sites of inflammation [ 12].