Indeed, although the majority of TNDM cases have an abnormality in chromosome 6q24 and the other most frequent causes of NDM are missense mutations in the pancreatic β-cell KATP channel genes KCNJ11 and ABCC8, and in the preproinsulin gene, NDM has been linked to numerous other genetic causes including point mutations in GCK, GLIS3, EIF2AK3, PDX1, PTF1A, SLC2A2, HNF1B or FOXP3 [2], [3], [3].
167 Candidate gene screening has revealed numerous other genetic causes of BrS.
Acquired resistance to BRAF inhibitors (BRAFi) is a near-universal phenomenon caused by numerous genetic and non-genetic alterations.
Mild reductions in endolysosomal degradative capacity may be caused by numerous genetic polymorphisms as well as an increased degradative load in various degenerative disorders characterized by intracellular accumulations.
Its causes are likely to be complex, and may involve numerous genetic and environmental risk factors (Flint and Kendler, 2014).
During this process numerous genetic mutations are lost from the population while mutations which occur concurrently with drug resistance causing mutations (or 'hitchhiking SNPs') remain [ 14].
Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express varying degrees of clinical illness, most commonly causing chronic diarrhea, abdominal pain, and bloating.
Numerous genetic defects, most of which can be detected by transmission electron microscopy (TEM), are so far known to cause different abnormalities of the ciliary axoneme.
They quickly found the genetic causes.
Tularik specializes in addressing the genetic causes of cancer.
