Sentence examples for numerous genetic abnormalities from inspiring English sources

Numerous genetic abnormalities are known in AML, among which chromosome translocations involving the MLL gene are associated with poor prognosis.

In addition, lung cancer involves numerous genetic abnormalities with turn-on and turn-off expression at different stage of the tumor.

Although numerous genetic abnormalities, including MYCN amplification, are associated with tumour progression and poor outcome, the molecular mechanisms responsible for the pathogenesis of aggressive neuroblastoma remain unclear.

It has been well-established that numerous genetic abnormalities are involved in HCC; comprehensive genomic analyses shows that components of the phosphatidylinositol-3 kinase (PI3K /Akt/mTOR pathway are dysregulated in 40-50% of HCC [ 5- 7].

CI: confidence interval; HR: hazard ratio; n: number of samples The phenotypic heterogeneity of cancer arises as a consequence of numerous genetic abnormalities (such as somatic mutations and chromosomal aberrations) acquired during tumor development and results in the formation of a disease that is enormously complex and highly variable between patients.

This in turn has led to the identification of numerous new genetic abnormalities associated with dystrophic or non-dystrophic disease of the striated muscles.

Next generation sequencing (NGS) analysis of DLBCL has facilitated global identification of numerous and diverse genetic abnormalities in these neoplasms and has shown that GCB and ABC tumours have different mutation profiles.

Human Barrett's cancer cell lines have numerous, poorly-characterized genetic abnormalities and, consequently, those lines have limited utility as models for studying the early molecular events in carcinogenesis.

Accordingly, numerous genetic studies have identified miRNA abnormalities in human cancers by dissecting their transcriptional regulators [19], [21], [22].

The approach will be broadly applicable for many types of genetic abnormalities, and should reveal numerous, previously unrecognized, mRNA splicing mutations in exome and complete genome sequences.

> -wrap-foot> n. a. not available Recent advances in the field of epigenetics have shown that human cancer cells harbor global epigenetic abnormalities in addition to numerous genetic alterations (Sharma et al. 2010).