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Such OA osteoblastic phenotype is more marked in the subchondral bone plate than in the trabecular bone, located at one centimeter of the cortical plate (Lavigne et al. 2005), and consisting in the up-regulation of numerous genes coding for extracellular matrix proteins, secreted cytokines and growth factors, and cell membrane proteins.
Suberin also induced major alterations in numerous genes coding in uncharacterised clusters (AN9234, AN9227, AN9230, AN11202, AN8106 and AN8520).
In addition, there are numerous genes coding for transcription regulators and signal transduction proteins that are indirectly regulated by CgrA.
Numerous genes coding for corresponding GTPase activating proteins (GAP) and Guanine nucleotide exchange factors (GEF) are present in the Bgh genome.
Although numerous genes coding for enzymes involved in such biochemical pathways have been identified, the molecular control of this process has been scarcely studied.
In regards to inner membrane receptors, there are numerous genes coding for ABC transporter subunits that also undergo significant changes in expression during cyst development.
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Beyond hydrocarbon degradation, numerous other functional genes coding for processes such as carbon fixation, nitrogen fixation, ammonium-oxidation, nitrate reduction, organic contaminant degradation, and metal reduction/resistance were observed (Table 2; Table S1).
Although the genes coding for the numerous G. theta Hbs are part of the nuclear and not the nucleomorph genomes, their very presence is remarkable in a unicellular organism that has undergone two endosymbiotic events and the succeeding, extensive reductions and processing of the plastid and nucleomorph genomes.
Numerous reports suggest that HGT with replacement of genes coding for functioning adaptive proteins are potentially highly disruptive.
In general, the genes in Table 1 encode a functionally diverse group of genes coding for proteins which are involved in numerous key pathways.
The genome of strain Rue61a contains numerous genes associated with osmoprotection, and a high number of genes coding for transporters.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com