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For example, numerous gene sets related to GABA-ergic neurotransmission emerged as highly significant in 4 out of 5 platforms.
In addition to differentially expressed genes, various signal transduction pathways for activating or repressing numerous gene sets are also involved in the process of embryogeny acquisition [ 7].
Profiling the expression of numerous gene sets in normal versus pathological states can provide critical clues to intracellular signaling pathway function, as well as to identities of genes that play important roles in carcinogenesis.
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Although the numerous gene-set analysis methods propose different measures of association (statistics), they all attempt to use the framework of statistical hypothesis testing to assess significance of association and, hence, assign a P-value to the gene set.
Evidence of differential connectivity was observed for numerous additional gene sets implicated in other carcinomas, though not previously with breast cancer.
We identified numerous gene duplications creating sets of orthologous and paralogous genes.
Numerous gene expression data sets for Synechocystis under diverse environmental and genetic conditions (see additional file 1) have accumulated in the literature and public databases.
Among the numerous inferred condition-specific regulatory associations between gene sets and TFs, also many novel putative regulatory mechanisms, such as the possible role of Tye7 in sulfur metabolism, were identified.
CBPLNs revealed numerous meaningful connections between different biological processes and gene sets, which we were successful in interpreting within the context of liver metabolism.
This may explain why the majority of the 852 gene sets that we examined, including numerous apoptosis and signaling pathways, did not show enrichment by chemotherapy response.
Many such cytoprotective genes are transcriptionally induced by oxidative stress, and numerous transcription factors are required to activate overlapping, but distinct gene sets upon oxidative stress (Ma, 2010).
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