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The advent of high-throughput techniques has produced numerous gene sequences, and annotating each enzyme reaction based on experimental results is difficult.
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The imminent completion of genome sequence information for major helminth parasites [ 32- 34] accentuates the problem of how to identify functional immune modulators among numerous novel gene sequences.
Causing collateral damage to the B-cell genome during CSR and SHM, AID induces unwanted (and sometimes oncogenic) mutations at numerous non-immunoglobulin gene sequences.
In reconstructed phylogenetic trees strain KT71T belongs to a branch comprising the recently described species Haliea salexigens and Spongiibacter marinus as well as numerous 16S rRNA gene sequences retrieved from uncultured marine bacteria (Figure 1).
Numerous 16S rRNA gene sequences have been described previously.
The post-genomic era has later provided numerous hemoglobin protein and gene sequences from a variety of organisms and even from extinct species to investigate evolutionary conserved positions as well as adaptive changes in specific lineages.
There are, however, numerous potential sources for orphan gene sequences that must be thoroughly investigated in light of their high representation in sequenced genomes and transcriptomes.
Numerous tests targeting many different gene sequences have been developed over the last decades, with the ribosomal DNA internal transcribed spacer 1 sequence [ 25– 27], or sequences within the kinetoplast DNA of Leishmania genus as the main targets [ 28, 29].
Using genome-wide location analysis, it was demonstrated that, upon genotoxic stress, SIRT1 is delocalized from repeat sequences and numerous gene promoters to bind to sites of DNA damage, in a process consistent with the afore-mentioned "RCM" hypothesis (for redistribution of chromatin modifiers).
Despite extensive divergence in sequence and numerous gene losses, these genomes retain perfectly conserved synteny.
Broader comparative analysis among sequenced red algae reveals numerous gene losses from the G. sulphuraria mitogenome (fig. 3).
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