The general conclusion from these studies is that the genetic architecture of these traits is complex and affected by many loci, with numerous gene-by-gene interactions (e.g. epistasis) and extensive genotype-by-environment interactions reported in a diverse group of organisms [ 10- 13].
Plasma triglyceride levels are determined by numerous genes and their interactions with the environment.
We focused mainly on transitive relationships with path of length two and used the developed software framework to detect and supplement missing new biomolecular annotations, according to the numerous gene and protein annotation and interaction data integrated in our GPKB (Table 1).
On the other hand, longevity is likely a complex, polygenic trait, which could be influenced by numerous gene-environment and gene-gene interactions, including those interactions between genetic variants that might not influence longevity individually.
In this study, Gromak, Proudfoot, and colleagues show that Drosha-DGCR8 binds numerous gene promoters not to cleave RNA but, rather, to form a molecular interaction surface.
Practically, gene interactions are nonlinear [3] [5].
C. jejuni and C. coli have been shown to be versatile and diverse species, harbouring numerous genes related to host interactions or metabolism that are not present in all strains, or are subject to phase variation [ 20, 30, 40- 42].
Each TCM herb may contain various ingredients and involve several biological pathways through its interactions with numerous genes, which could be supported by one or many literature evidences; and these interactions may help in the discovery of new therapies for diseases.
Almost all inherited features or traits are the products of complex interactions of numerous genes.
Moreover, biological functions are not, in general, realized by individual proteins, but, rather, by networks of intricate interactions between numerous genes.
