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Here, numerous gene conversion events haven been detected in the LRR regions, promoting the generation of chimeric genes and novel resistance specificities.
Analysis of this polymorphism in isolates representing a broad spectrum of M. tuberculosis lineages shows that numerous gene conversion events have occurred between these genes throughout the evolutionary history of the PGG2 and PGG3 groups.
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There are numerous likely gene conversion tracks resulting from both inter- and intra-locus events between pairs for both of these sets of paralogs.
Furthermore, there are numerous occasions for gene conversion events through sequential infections at the same anatomic sites.
Gene families in Lepidoptera encoding the structural chorion proteins are characterised by numerous gene duplications, occasional subsequent gene loss, gene conversion, and in general rapid sequence divergence [ 61, 179].
The large number of duplicated repeats between chromosomes provides numerous opportunities for inter-chromosomal gene conversion.
Gene conversion has been reported in other mammalian genes.
Gene conversion occurred only between duplicates of a given gene.
A somewhat different use of gene conversion between silent and expressed cassettes takes place in numerous disease microbes (pathogens), both bacteria and eukaryotes.
There are other examples of possible complete gene conversion events occurring between species-specific Alu elements, where pairs of elements share numerous mutations.
These multigene family members emerged from numerous duplication events or replicative transpositions and evolved by a combination of birth-and-death processes, gene conversion events and purifying selection (e.g. [ 20- 22]).
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