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Numerous gain and loss of function studies in several cancer types (gastric cancer, ovarian cancer and hepatocellular carcinoma) reinforced the link between SOX2 and cellular invasion and migration [15, 37, 47, 55].
Numerous gain and loss events were observed for uni-cIntFams at all phylogenetic levels (Fig. 3c, Table S5).
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In general, the tumours showed numerous gains and losses of large chromosomal regions.
The samples showed numerous gains and losses of large chromosomal regions.
In general, the samples showed numerous gains and losses of large chromosomal regions.
Evidence from numerous gain-of-function electroporations showed that ectopic expression borders of Krox20 or of hindbrain Hox proteins from paralogue groups 1 to 4 are sufficient to initiate cell segregation and apical remodelling.
NULMS are characterized by different gene alterations, complex karyotypes with numerous gains and losses.
Breast cancers are genomically highly instable, and array Comparative Genomic Hybridization (aCGH) analysis shows numerous gains and losses of whole chromosomes or parts of chromosomes.
Furthermore, the complement of tRNA genes likely changes over evolutionary time in Drosophila, with evidence of numerous gains, losses, and reassignments (Rogers et al. 2010).
It was demonstrated that ancestral eukaryotic forms were intron-rich and that evolution of eukaryotic genes involved numerous gains and losses of introns, with losses being somewhat more common.
IMPCs presented with complex genomic profiles and numerous gains, losses or high-level amplifications as well as numerous breakpoints, and, in line with their luminal phenotype, demonstrated a genomic profile that shared similarities with that of ER+N+LVI+ IDC-NSTs with regard to 8q gains and 8p, 16q and 22q losses.
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