Numerous functions have been assigned to these proteins, including osteoblast/osteocyte differentiation, bone formation, solubilization of the osteoid during bone resorption, osteoclast recruitment and migration, and as a coupling factor in bone remodeling under physiological conditions.
Numerous functions have been assigned to octopamine including regulation of lipid versus carbohydrate metabolism in insect flight muscle [3], [4], increasing levels of arousal [5] [7], modulation of sensory perception [8] [12], aggression [13], [14], control of locomotion [15] [17] and signaling the presence of reward in appetitive olfactory learning [18] [21].
Numerous functions have been unravelled for members of this protein family.
In fungi, numerous functions have been proposed for polyketides, including the production of toxins [ 27, 28] and spore pigments [ 29, 30].
Numerous functions have been shown to depend on normal lysosomes, including turnover of cellular constituents, cholesterol homeostasis, downregulation of surface receptors, inactivation of pathogenic organisms, repair of the plasma membrane and bone remodeling.
Numerous functions have been ascribed to RBM5 gene products, including tumor suppression [ 11, 17], apoptosis modulation [ 17- 19], cell cycle regulation [ 20] and RNA binding [ 5, 12], however, the mechanism of action of the full-length RBM5 protein is only just beginning to be delineated [ 17].
Numerous pedotransfer functions have been suggested so far to relate the soil BD values to soil parameters (e.g. soil separates, carbon content, etc).
Numerous effector functions have been attributed to IL-18.
Although numerous biological functions have been attributed to prions, their exact physiological role is still not known.
Housing was originally devised as a control of the thermal environment, but numerous other functions have been added with resulting competition and confusion.
This is not a novel concept and in various small-scale studies, numerous gene functions have been examined based on the increased sensitivity of their gene deletion strains to different compounds [ 8, 9].
