The structural basis for their numerous functions is a complex and dynamic double-membrane architecture.
Spiegelman and collaborators [ 34, 35] asked bacteriophage Qβ only to "go forth and replicate" in the medium containing Qβ replicase, and numerous functions were lost.
Numerous functions have been assigned to these proteins, including osteoblast/osteocyte differentiation, bone formation, solubilization of the osteoid during bone resorption, osteoclast recruitment and migration, and as a coupling factor in bone remodeling under physiological conditions.
Numerous functions have been assigned to octopamine including regulation of lipid versus carbohydrate metabolism in insect flight muscle [3], [4], increasing levels of arousal [5] [7], modulation of sensory perception [8] [12], aggression [13], [14], control of locomotion [15] [17] and signaling the presence of reward in appetitive olfactory learning [18] [21].
Numerous functions have been unravelled for members of this protein family.
In fungi, numerous functions have been proposed for polyketides, including the production of toxins [ 27, 28] and spore pigments [ 29, 30].
Numerous functions have been shown to depend on normal lysosomes, including turnover of cellular constituents, cholesterol homeostasis, downregulation of surface receptors, inactivation of pathogenic organisms, repair of the plasma membrane and bone remodeling.
Numerous functions have been ascribed to RBM5 gene products, including tumor suppression [ 11, 17], apoptosis modulation [ 17- 19], cell cycle regulation [ 20] and RNA binding [ 5, 12], however, the mechanism of action of the full-length RBM5 protein is only just beginning to be delineated [ 17].
Knowing that numerous cell functions are regulated by mechanical signals, it is of key importance to quantitatively taken into account the influence of the fiber alignment on the tensile properties of such biomaterials as they will determine suitability of the materials for specific applications.
In both developing and mature organisms, numerous physiologic functions are regulated by T3 availability, including energy metabolism, thermogenesis, pituitary hormone production, and lipogenesis (Yen 2001).
