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Numerous feedback loops and functional redundancies make vulval development relatively insensitive to small perturbations in signaling pathways.
Behaviors produced by healthy physiologic systems, however, rely upon nonlinear interactions among numerous feedback loops and regulatory processes that operate over multiple temporal and spatial scales [ 24, 36].
Numerous feedback loops exist within and between biology and marine and atmospheric climate, which we are only beginning to understand, e.g. [ 2, 3].
Numerous feedback loops coordinate the activities of these two cell types (213), one of which is inhibition of the resorptive activity of osteoclasts by high local extracellular Ca2+ concentrations, which trigger an increase in cytosolic Ca2+ concentration (214).
The gastrointestinal tract is a very sophisticated and complicated organ, characterized by a high metabolic rate, enteric nervous plexus with numerous feedback loops, intermingling connections of various enzymes and hormones, and enormous turn-over of metabolites and toxins.
Experimental approaches have revealed numerous feedback loops in tumor cells and have shown that blocking one signaling pathway, be it the receptor [ 22, 23] or downstream targets [ 24, 25], is not sufficient to cause tumor regression, thereby allowing resistant cells to emerge.
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The 'chain-linked'/integrated innovation process model (fourth generation) considered the innovation process as fundamentally a parallel process in which the corporate functions are connected through numerous backward (feedback) loops (Kline and Rosenberg 1986).
Furthermore, several lines of evidence support that a complex network of proinflammatory cytokines and numerous positive feedback loops perpetuate the chronic inflammation.
Numerous linkages and feedback loops occur between the soil-geomorphic template, microclimate, vegetation, and animals.
Also, the loopless structure of the network is not typical for the underlying microscopic brain connectivity, which consists of numerous feedback and feedforward loops, making this network somewhat more indirect.
In any event, and insofar as innate immune responses in fish embryos can be equated to mammalian cellular activities, these responses are likely to be very complex, with numerous endogenous mediators, feedback loops and time-dependent variation.
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