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To tag numerous endogenous genes in Drosophila, protein trapping methods were previously developed based on screening untargeted insertions of transposable elements carrying a protein trap cassette.
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Because of the complex systems of metabolism of numerous endogenous and exogenous compounds, it is likely that gene variants associated with increased risk only among populations with specific exposures will be overlooked when searching for the main effects of SNPs.
Cytochrome P450 (CYP) enzymes play important roles in the biotransformation of numerous endogenous compounds as well as drugs and chemical carcinogens 1, 2; in humans, 57 functional or potentially functional CYP genes have been identified.
Imaging transcription dynamics at endogenous genes in living Drosophila tissues.
Of these techniques, gene cassette knock-in is especially useful for monitoring endogenous gene expression and localization, which is essential for functional annotation of endogenous genes.
The introduction of suicide genes may disrupt endogenous genes, leading to tumourigenic mutations21.
Two endogenous genes, acaA and pkaC, were selected as target genes (Fig. 3B).
Positive and negative regulation of endogenous genes by designed transcription factors.
Amabile, A. et al. Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing.
Fimiani, C., Goina, E. & Mallamaci, A. Upregulating endogenous genes by an RNA-programmable artificial transactivator.
(e) The induction of endogenous genes after nitrate treatment in WT, nlp7-4, aNRT1.1/nlp7-4 NRT1.1/nlp7-4
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