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Utilizing a cDNA microarray developed at the center, researchers can test numerous end points.
These studies examined numerous end points, with changes in motor activity and muscarinic acetylcholine receptor density the most common.
The review encompasses both high- and low-dose studies involving pre-, neo-, and postnatal exposures and numerous end points.
In rabbits, the most numerous end points (k) were embryonic fetal loss (k = 23), skeletal axial defects (k = 17), and fetal weight reduction (k = 15).
The protocol of the studies attempts to capture numerous end points and informative parameters, including those unrelated to traditional GH treatment end points.
An ideal dose response trial is placebo controlled, uses multiple doses or a controlled dose-escalation schedule, consists of repeated visits with collection of numerous end points over time and controls for all potential sources of variability.
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In any event, evidence is mounting that exercise programmes are safe and beneficial for numerous end-points, including strength, fatigue, and quality of life.
Numerous other end points have been found to be associated with arsenic exposure.
The fractions may be tested with a broad range of microbial assays covering numerous genetic end points as well as both with and without mammalian microsomal activation.
Numerous biological end points were assessed; growth responses were the most prevalent, followed by metabolic effects, longevity, reproductive responses, and survival.
Considering the need to rapidly screen tens of thousands of anthropogenic compounds, our study shows the feasibility of using combined HTS assays as a novel approach toward obtaining toxicologic data on numerous biological end points.
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