Defects in biological mechanisms controlling protease activities can have numerous effects, such as neurodegeneration, cardiovascular diseases, osteoporosis, arthritis, and metastases of cancers [ 5].
Inferring heterogeneity from RNA-Seq is very difficult due to the co-occurrence of numerous effects, such as allele-specific expression, varying expression levels across subclones, and alternative splicing, all of which can alter the allelic balance.
Our observation that deficiency of a single gene may neutralize the cancer preventive benefit of a methyl-balanced diet shows that at least one of the numerous effects of such diet may play a rate-limiting role in the cancer prevention process.
The fully electric Savoy made possible numerous special effects, such as sparkling magic wands for the female chorus of fairies.
By modifying the expression of its target genes, c-Myc regulates numerous biological effects, such as cell proliferation, senescence, angiogenesis, metabolism, and genetic stability [8].
However, repetitive treatment with CP is associated with numerous side effects such as nephrotoxicity, neurotoxicity, and reproductive toxicity [ 3].
Indeed, their utility in treating various diseases is, however, limited by numerous side effects such as growth failure and decreased bone quality [ 47].
Especially when dealing with results from different studies, it is important to examine the control-treatment differences, rather than the absolute lifespan variations, which are influenced by numerous other effects, such as temperature or food type.
Triple therapy has an efficacy of 75% but is expensive and associated with drug resistance and numerous side effects, such as observed with allergy and cardiovascular drugs, while sequential therapy has an efficacy of 90% or greater.
Current therapeutics targeting one or more of the three plasma membrane monoamine transporters (MATs), those for the substrates serotonin (SERT), norepinephrine (NET) or dopamine (DAT), carry numerous adverse effects such as gastrointestinal disorders, increased hunger, insomnia/hypersomnia, and impotence.
Reactive oxygen species produced by ultraviolet light, ionizing radiation, chemical reactions, and metabolic processes have numerous pathological effects, such as causing lipid peroxidation, protein peroxidation, DNA damage, and cellular degeneration related to a variety of diseases including Alzheimer's disease [ 54, 56].
