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Among its numerous effects in cells, IGFBP5 can regulate migration and differentiation [42], [100], [101].
Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood.
Signaling mediated by this class of bioactive lipids, which are collectively referred to as eicosanoids, has numerous effects in physiological and pathological processes.
Sonic hedgehog (Shh) is a secreted signaling protein acting through the Gli-family of transcription factors with numerous effects in vertebrate development.
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27, 28 TNF-α has numerous effects important in the pathogenesis of psoriasis and PsA.
Numerous effects of cardiac glycosides in cancer cell lines ultimately leading to apoptosis have been demonstrated previously.
Biomarkers therefore can target numerous effects, including increased turnover in cartilage and bone, fibrillation, subchondral bone thickening, bone edema, osteophytes, focal cartilage lesions, and eventually cartilage denudation (see models of OA stages [ 42, 43]).
Thus, it seems that at least some of the numerous effects connected with caffeine interference in the functional effectiveness of the S-phase checkpoints are connected with mechanisms independent of its inhibition influence on the ATM and ATR kinases.
Ongoing research has discovered that SPP1 in MPE due to lung cancer has numerous effects: it progresses the tumor both in its growing and metastasis, and prolongs the survival of cancer cells [ 16].
Owing to the heterogeneity of the disease, numerous effects will be observable concurrently in a population, and therefore aggregate markers may allow more comprehensive quantification in clinical studies.
As discussed above, EGFR inhibition has been shown to have numerous effects that could lead to increased in vitro radiosensitization.
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