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In Fig. 1 some of these numerous effects are plotted by effective doses or concentrations, an approach already proposed by other authors [59].
For PFOS, numerous effects are reported, e.g. hepatic damage, disturbance of DNA metabolism [14] and adverse effects on protein expression [15].
In the nonparametric kernel regressions (ELM and ULM), the numerous effects are estimable by smoothing the phenotypes against one predictor at a time, assuming that the effects of the remaining are removed from the phenotypes.
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Although numerous effects have been described for resveratrol and curcumin, however, the mechanisms responsible for their anti-inflammatory effects in chondrocytes are not yet clear.
To date, although numerous effects have been made to develop therapies based on antioxidants in the past years, the actual benefits to the patients have been very limited.
Numerous adverse effects are associated with the accidental release of ethanol (EtOH) and its persistence in the subsurface.
Exogenous bone morphogenetic proteins (BMP) have been utilized to positively regulate matrix mineralization and osteoblastogenesis, however, numerous adverse effects are associated with this approach.
The site-specific natural sensitivity, the impact of varying and until now not documented farm management practices, and their numerous reciprocal effects are difficult to grasp in a mutual method.
Numerous side effects are associated with synthetic drugs used in treating hepatic disorders.
Furthermore, numerous side effects are often experienced following treatment (Chen et al, 2007; Lips et al, 2008), even with more recent technological developments, such as stereotactic body radiation therapy (Cyberknife) (Woo et al, 2014).
It is thus clear that numerous 3-D effects are characteristic for the Central Andean data set.
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