Sentence examples for numerous downstream targets from inspiring English sources

Following introduction of DSB, ATM undergoes auto-phosphorylation at serine 1981 and its kinase function is activated, leading to phosphorylation of numerous downstream targets [20], [21].

AKT signaling through numerous downstream targets governs the metabolic effects of insulin.

Furthermore, these investigators showed that β-catenin enhanced gastrin promoter activity, thus identifying gastrin as one of its numerous downstream targets.

Once bound, RA is delivered by CRABP and FABP5 to retinoic acid receptor (RAR) or peroxisome proliferating receptor (PPAR), respectively, where it alters transcription of numerous downstream targets.

Numerous downstream targets of the microRNA-17-92 microRNA-17-92 microRNA-17-92 providing evidenclustert thavencogenic mechanisms mediated beenhidentifiedA.

The possibility of multiple functions for foraging within a species is not entirely surprising as the foraging gene encodes for a protein kinase that is expected to have numerous downstream targets [ 8].

ROCK controls actin-cytoskeleton assembly and cell contractibility by phosphorylating numerous downstream target proteins [3], such as the regulatory myosin light chain (MLC) and the actin-binding LIM kinases.

The ligand (RA) activates its nuclear receptors (RAR and RXR), which can form heterodimers with other ligand-dependent transcription factors (e.g., LXR, PPARG and THR) to initiate transcription of numerous downstream target genes.

Recent studies have revealed that Wnt signal transduction plays a pivotal role in human tumor development, where it mediates the transcription of numerous downstream target genes associated with increased growth and invasion [ 17].

The Rho-associated coiled-coil containing protein kinase (ROCK) serine/threonine kinase is a major downstream effector of Rho GTPases that controls actin cytoskeleton assembly and actomyosin contractility via the phosphorylation of numerous downstream target proteins, including the myosin light chain (MLC) and actin-binding Lin11, Isl-1, and Mec-3 domain (LIM) kinases.

Ligand binding induces γ-secretase-mediated cleavage and translocation of Notch intracellular domain into the nucleus, where it interacts with the DNA-binding protein RBP-J to induce the expression of numerous downstream target genes, such as Hes-1 and Deltex-1.