Sentence examples for numerous downstream genes from inspiring English sources

HVEM engagement by LIGHT leads to signaling through the NF-κB family of transcription factors, subsequently influencing numerous downstream genes encoding adhesion molecules, chemokines, and cytokines [45].

This would compromise gene regulation and hence the function of numerous downstream genes and vital biological processes, including the development of transmission stages.

In many studied species, altering the synthesis or activity of sigma factors can lead to changes in the expression of numerous downstream genes.

The AG transcription factor orchestrates the expression of numerous downstream genes (Gómez-Mena et al., 2005; Ito et al., 2007; Ito et al., 2004).

In fact, various studies have reported that EGF and TGF β can induce the phosphorylated form of p68 to bind beta-catenin, resulting in nuclear translocation of the latter with the activation of numerous downstream genes.

An overwhelming majority of these genes were down-regulated in the mutant strain indicating that AfsS is primarily a direct or indirect positive regulator of transcription for numerous downstream genes.

The ligand (RA) activates its nuclear receptors (RAR and RXR), which can form heterodimers with other ligand-dependent transcription factors (e.g., LXR, PPARG and THR) to initiate transcription of numerous downstream target genes.

Recent studies have revealed that Wnt signal transduction plays a pivotal role in human tumor development, where it mediates the transcription of numerous downstream target genes associated with increased growth and invasion [ 17].

Ligand binding induces γ-secretase-mediated cleavage and translocation of Notch intracellular domain into the nucleus, where it interacts with the DNA-binding protein RBP-J to induce the expression of numerous downstream target genes, such as Hes-1 and Deltex-1.

DREB2-type transcription factors respond to an array of stressors (i.e. dehydration, salinity, cold, heat and exogenous ABA) and are documented to induce the expression of numerous, downstream, abiotic-stress related genes.

The possibility of multiple functions for foraging within a species is not entirely surprising as the foraging gene encodes for a protein kinase that is expected to have numerous downstream targets [ 8].