Numerous disorders cataloged in Online Mendelian Inheritance in Man; http://www.ncbi.nlm.nih.gov/omim/(OMIM) 116 are associated with epileptic seizures.
Hence, it is not surprising that in numerous disorders, a dramatic reduction in KGDH activity is observed [22], [23].
Numerous disorders can result in episodic paroxysmal events that may mimic epileptic seizures.
Observations of altered resting state connectivity in the brain in numerous disorders (Fox and Greicius, 2010) and as a function of behavior or cognitive skills suggest that such correlations reflect an important level of organization and may play a fundamental role in the execution and maintenance of various functions (Pizoli et al., 2011).
The identification of arrestin-binding sites for various signaling molecules will also set the stage for designing molecular tools for therapeutic intervention that may prove useful in numerous disorders associated with congenital or acquired disregulation of GPCR signaling.
The link between cognitive performance and global functioning/quality of life has been established in numerous disorders including schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, and Alzheimer's disease [1], [2].
Neuronal sensitivity to rab7-dependent degradation may be a common factor contributing to neuronal pathology in numerous disorders with reduced degradation or increased degradative burden.
Consistent with this hypothesis, exposure to fear-inducing stimuli has been demonstrated to increase activity in the amygdala of human subjects (Breiter et al., 1996; Morris et al., 1996; Rauch et al., 2000), and hyper-amygdala activation is observed in numerous disorders, including post-traumatic stress disorder (Rauch et al., 2000).
However, this is worthy of further exploration: despite its deserved reputation as a potent toxin, the physiological actions of endogenous CO, and its potential as a therapeutic agent in numerous disorders, is increasingly being recognized (e.g. Motterlini et al).. Future studies will reveal whether it may also be of benefit in combatting neurodegenerative diseases.
