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Many of these differences between ordered and intrinsically disordered proteins were utilized to develop numerous disorder predictors.
Amino acid differences between IDPs and ordered proteins have been utilized to develop numerous disorder predictors, including PONDR® (Predictor of Naturally Disordered Regions) [ 9], charge-hydropathy plots (CH-plots) [ 14] and IUPred [ 15] to name a few.
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Alterations in the concentration and subcellular localization of ROS are integral to numerous disorders, including neurodegenerative diseases and cancer.
Peptides and peptide‐based drugs are increasingly being utilized as therapeutic agents for the treatment of numerous disorders.
Numerous disorders cause kidney fibrosis including glomerulonephritis, diabetic nephropathy, SSc with kidney involvement and rare disorders such as immunoglobulin A nephropathy [158].
The deletion of genes for BER were lethal in mice [11], while mutations affecting NER and TCR were associated with numerous disorders and accelerated aging [12, 13, 14].
Gene therapy, the introduction of therapeutic genetic material to cells to ameliorate disease or injury, holds great potential for the treatment of numerous disorders.
Although vitamin D deficiency is associated with an increased risk of numerous disorders, no previous study has investigated its association with sexual dysfunction.
Mitochondrial defects are the cause of numerous disorders affecting the oxidative phosphorylation system (OXPHOS) in humans leading predominantly to neurological and muscular degeneration.
These therapies hold great promise for treating numerous disorders of the central nervous system (CNS) including novel approaches to chronic pain management.
N-acetylcysteine (NAC), a cysteine pro-drug and glutathione precursor has been used in therapeutic practices for several decades, as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication.
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