Sentence examples for numerous disease models from inspiring English sources

There are numerous disease models for which gene expressed shRNAs or microRNA mimics are being tested in animal models.

This compound is the most well-studied SphK inhibitor in vivo in that it has been deployed in numerous disease models.

These results show some of the dynamic processes involved in the evolution of the Y-chromosome and suggest importance in numerous disease models such as hypertension.

However, a rise in intestinal permeability caused by MLCK activation was demonstrated in numerous disease models, including endotoxemia, pro-inflammatory stress, giardiasis and T cell-activated colitis [ 15- 17].

Although much of these early works were performed using in vitro assays, more recently the role of JAM-C in inflammation and vascular biology has been investigated in vivo within numerous disease models.

Through the use of JAM-C-deficient mice and/or blocking antibodies, the role of JAM-C has been investigated in numerous disease models such as models of arthritis (12), peritonitis (13), acute pancreatitis (14), ischemia-reperfusion injury (11), and pulmonary inflammation (15, 16).

Initially employed as a model of developmental biology, in the last 15 years zebrafish research has extended to include disease modelling, and there are now numerous diseases modelled in the zebrafish, from tuberculosis to Parkinson's disease (Flinn et al., 2008; Renshaw and Trede, 2012; Torraca et al., 2014).

Vectors based on adeno-associated virus (AAV) have proven themselves to be highly promising in numerous retinal disease models, but they are also incapable of Muller cell infection.

Numerous experimental disease models (including sepsis, ischemia-reperfusion injury and arthritis) responded to therapy targeting HMGB1, which might indicate that removing or neutralizing HMGB1 attenuates innate immune system activation and reduces tissue damage [ 21].

In numerous instances, infectious disease models have played a key role in informing data collection, including the Garki project studying malaria, the response to the 2009 pandemic of H1N1 influenza in the United Kingdom and studies of T-cell immunodynamics in mammals.

The expert panel then issued a consensus statement (vom Saal et al. 2007), which concluded that low environmentally relevant doses of BPA could cause numerous diseases in animal models, and that there was evidence for both low-dose effects and for nonmonotonic dose response relationships.