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Adiposity therefore seems to have the genetic profile of a continuous trait that is affected by numerous different genes, whose number and variability across populations remain to be established.
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An advantage of this signature is that it was clustered in 13 clusters of highly correlated genes from which numerous different 13-gene signatures were evaluated and found to have nearly the same performance as the complete signature.
Some genes have extensive complexity in both genetic variation and the resulting phenotype, and numerous SNPs from different genes were associated across these three trait categories, suggesting that tree growth and wood biosynthesis are complex, dynamic processes that require the coordinate regulation of diverse sets of genes.
In contrast, when we analyzed the sites bound by H3K9me3 but not by SETDB1, we observed enrichment in numerous different functional categories including genes involved in signaling through phosphorylation, amino acid transport, cell adhesion, metabolism and development (using a p-value <1e-3; SupplementaryTableTable S6).
There were numerous cases where two different genes were identical within a region that was variable among family members as a whole, suggesting recombination among family members.
As recent reports on the Human Genome Project have acknowledged, "gene splicing" in higher organisms can produce numerous different proteins from a single gene.
The molecular etiology of those tumors involving dMMR is very heterogeneous, involving several different genes and numerous mechanisms of gene inactivation, including epigenetic, somatic and germline alterations.
However the patchiness of the Aspergillus species represented by the different genes suggests numerous rearrangements and gene losses in these species.
Genetic diagnosis in HHT is difficult, as mutations occur in numerous different locations in the linked genes, without particular mutations being highly frequent (as opposed to, for instance, the ΔF508 mutation in cystic fibrosis).
Given that genes with high regulatory load are important for the cell identity and often expressed in a cell type-specific manner, we decided to analyze the expression levels of the macrophage metabolic model genes across numerous different cell types.
Among those, it is important to note that numerous different mutations in the AID gene have been identified in HIGM2 patients, whose impact on the efficiency of the CSR and SHM reactions is highly variable [7], [41], [43], [44].
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