Sentence examples for numerous developmental defects from inspiring English sources
The numerous developmental defects we identified in these mice demonstrate an essential role for Esrp-regulated splicing in the development of many organ systems.
Also knockdown of Lid, the KDM5 family orthologue in Drosophila, causes numerous developmental defects through deregulation of homeotic gene expression [ 60].
Small perturbations in N activity lead to numerous human developmental defects and diseases including cancer, stroke, and dementia.
In addition to family stress and problems, disturbed social behaviour, problems at school and at work and the attendant impaired quality of life, numerous significant long-term pathological developmental defects are known [ 6, 7].
Defects in PTMs have been linked to numerous developmental disorders and human diseases, highlighting the importance of PTMs in maintaining normal cellular states.
Our work on the role of miRNAs during vertebrate development has also identified numerous miRNAs that are not highly abundant but whose disruption leads to specific developmental defects (Flynt et al. Nat Gen 39: 259; Li et al. Dev 138: 1817; Thatcher et al. PNAS 105: 10584).
STIL mutation in zebrafish causes an embryonic lethal defect [ 69], and STIL knockout mice (Sil-/) exhibit numerous developmental abnormalities at embryonic day E7.5-8.5 E7.5-8.5ander E10.5.
Given numerous studies that now directly link defects in cohesion pathways to aneuploidy and cancer (breast cancer and aggressive melanoma) and developmental defects (including Cornelia de Lange Syndrome, Roberts Syndrome/SC-phocomelia Syndrome/SC-phocomeliandrome), chandcterization of this neWarsawlass of anti-estaBreakaget factorSyndromes of great interest [38], [39].
There is no exception for microcephaly or other developmental defects caused by Zika.
In laboratory tests with rabbits, significant exposure to DMF has been proved to cause developmental defects.
Others are caused by developmental defects that occur in the womb.
