Numerous data suggested that the original site of inflammation is indeed the adipose tissue but recent studies, using conventional and germ-free mice, suggested that it could be localized into the intestine where HF Western diet and gut bacteria interact to promote intestinal inflammation, which contributes to the progression of obesity and insulin resistance [ 85].
Despite numerous data suggesting similar functions in vivo of human (hZFP57) and mouse ZFP57 (mZFP57) [3,5,13], these proteins share poor sequence identity outside the regions encompassing the KRAB domain (that binds the cofactor KAP1) and the third and fourth human and first and second mouse ZFs (Fig. 1).
However, in numerous cases, empirical data suggest that the fraction of genes preserved subsequent to duplication events is much higher than predicted by the classic model.
Numerous experimental and clinical data suggest that exogenous SMF can make profound effects on a large variety of biological systems.
Numerous epidemiological and experimental data suggest that the extremely low frequency magnetic field generated by electrical transmission lines and electrically powered devices and the high frequencies electromagnetic radiation emitted by electronic devices have a potentially negative impact on the circadian system.
Although many important questions remain unanswered, the available data suggest that numerous aspects of pregnancy, birth and early mammalian development can proceed under altered gravity conditions.
Our data suggest that numerous genes directly or indirectly involved in flowering regulation play pleiotropic roles in adaptation to environmental stresses, and thus represent important genetic factors to be considered for adaptive breeding.
Taken together, these data suggest that numerous activating factors are highly enriched at group I promoters, indicating a massive regulation, which consequently leads to higher transcriptional activity ('hyperactive') (Fig. 5c and d; Additional file 1: Figure S3e and f).
The pollen data suggest the survival of numerous temperate deciduous trees in sheltered and favorable habitats despite the harsh climate conditions.
