Sentence examples for numerous copy number from inspiring English sources

All of the NSCLC patients (100%) had copy number aberrations and each patient evidenced numerous copy number changes.

We observed numerous copy number alterations in most of the samples with a high rate of exclusive deletion encompassing 1p, 3p and 14q.

These studies identified over 20 common LOH regions, frequent copy number alterations (both gain and loss), as well as numerous copy number neutral regions, which suggests that this cancer is characterized by genomic instability [ 5, 6].

We have previously shown that bone-marrow-transduction-derived PRDM14 leukemias are highly aneuploid, harbor numerous copy number alterations (CNAs), and have altered expression of chromosome stability, DNA repair and recombination factors (Simko et al., 2012).

Likewise, 80% of aberrations detected by array CGH in tumour cells of the mouse model for epithelial ovarian cancer are conserved in human epithelial ovarian cancer [281] and epithelial carcinomas in mice with telomere dysfunction show numerous copy number changes in regions syntenic to those in human cancers [282].

These results suggest that most mouse groups are characterized by numerous DNA copy number changes, many of which are specific to a given model/group (Supplemental Table 4).

For example, mammalian genomes contain numerous high copy number TE families though only a few recently active TE families have been discovered [ 41].

Nonetheless the hallmark of HGSCs was numerous somatic copy number alterations, with more than 100 recurrent amplifications and deletions identified [ 11].

Affymetrix 500K SNP array analysis revealed all paediatric glioma cell lines to display complex genomes with numerous gross chromosomal copy number abnormalities and rearrangements.

Homozygous deletion at the CDKN2A/B locus at 9p12 was observed in the anaplastic astrocytoma UW479 line, which additionally harboured numerous high level copy number changes including 3p11-p12, 6p21, 18p11 and 19q12.

The Cancer Genome Atlas project (TCGA) revealed adult HGA to be highly heterogeneous with numerous mutations and copy number changes within tumors and across tumors sharing similar gene expression profiles [ 8, 12, 52, 72].