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Real-time PCR can be used to such a comparative end in a rapid and efficient manner without the need for building internal standard curves or utilization of numerous control genes.
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If, as our results appear to imply, excessive complexity and nonessential genes can arise due to circumstantial reasons and not in response to direct evolutionary pressure, this may make biologists suspect similar reasons behind the existence of numerous control circuits and redundant genes in living organisms.
-wrap> The clock-controlled transcription factors identified in this study have the potential to control numerous target genes, implying a wider circadian control of photoreceptor gene expression as well as photoreceptor function.
HIF-1 controls numerous genes of pivotal importance for cellular metabolism, angiogenesis, cell cycle regulation and inhibition of apoptosis.
Undoubtedly, PGC-1α plays a critical role in maintaining muscle metabolic function and controls numerous genes that affect a broad range of muscle morphology and physiological function.
MicroRNAs are small ∼22 nucleotide regulators of numerous biological processes and bind target gene messenger RNAs to control gene expression.
HDACs control gene expression through chromatin modification.
Variations in numerous other genes control the subtler details of the coat's colouration, which in yellow Labradors varies from white to light gold to a fox red.
These results strongly suggest a hierarchical organisation in which core clock components directly regulate the expression of a few tissue-specific transcription factors, which can then control numerous target genes by a transcriptional cascade.
miRNAs have been shown to control numerous genes involved in various biological and metabolic processes.
The MITF protein works together with partner proteins to control numerous genes, activating some while inhibiting others, by binding to nearby stretches of DNA that act as regulatory elements.
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