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Recent evidence suggests that DNA methylation changes may underlie numerous complex traits and diseases [ 19– 219.
Genome-wide association studies (GWAS) have been successfully applied to numerous complex traits in humans (Welter et al. 2014).
58, 59 These areas of genetic epigenetic correlation may underlie gene environment interactions and have been associated with numerous complex traits and disorders.
However, despite the numerous complex traits that have been analysed by genome-wide linkage studies, few of the underlying genes have been identified [22].
As part of the Korean Genome Analysis Project, Korea Association REsource KAREE) study was initiated in 2007 to conduct a large-scale genome-wide association study aiming to discover variants associated with Type 2 diabetes and numerous complex traits.
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Genome-wide association studies (GWAS) (now with >400 published studies) have been successful in identifying common variants associated with numerous complex quantitative traits and diseases [ 9].
However, negative characters in traditional varieties and the numerous and complex traits involved in salinity tolerance have presented challenges for conventional breeding to make significant progress and has led to increased interest in molecular breeding methods (Gregorio et al. 2002; Yamaguchi and Blumwald 2005; Ismail et al. 2007; Thomson et al. 2010).
We note that a combined analysis of GWAS SNPs for numerous complex diseases and traits did not show an enrichment for CTCF sites [ 48].
3 To discover and combine these additional genetic factors, statistical methods for the detection of associations of common variants have been extensively developed and successively applied to numerous studies of complex traits.
These frontal circuits influence numerous complex functions including cognitive and personality traits [ 27- 32].
However, the latter approach would be less efficient when applied to complex traits affected by numerous QTL of varying effects, while genomic selection is well suited to handle this situation.
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