Sentence examples for numerous client proteins from inspiring English sources

The ATPase cycle of the Hsp90 molecular chaperone is essential for maintaining the stability of numerous client proteins.

Since Hsp90 is a molecular chaperone that regulates the maturation, activation and stability of numerous "client proteins" including ALK, dual targeting ALK and Hsp90 may bring more benefits and efficacy against drug resistance of ALK inhibitors.

It has been shown that Hsp90 chaperone has numerous client proteins, and plays a key role in their folding, assembly, and activation [42].

The fungal Hsp90 interactome has numerous client proteins such as receptors, protein kinases, and transcription factors (Leach et al. 2012).

The 90-kDa heat shock protein HSP90AA1 is a chaperone protein associated with numerous client proteins that are highly expressed in many cancer cells [ 1, 2].

Hsp90 is a molecular chaperone able to directly bind, stabilize, and regulate the function of numerous client proteins, including many mediators of signal transduction and cell cycle progression [ 41].

Numerous types of misfolding events can activate ERAD, including environmental stressors or genetically encoded mutations in ERQC client proteins (Ward et al., 1995; Kelly et al., 2007).

Many oncogenic client proteins involved in formation of metastatic pathways.

Stabilization, regulation, and maintenance of these oncogenic client proteins are provided with Heat Shock Protein 90 (Hsp90).

Many oncogenic proteins are HSP90 client proteins.

They associate with nonnative client proteins following synthesis or damage and facilitate client sorting and folding.